Hydrochloric Acid → HCID 178488023, Verbindung

HRID 659825Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 659825
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[C:8]([OH:13])[C:7](O)=[N:6]2.O=S(Cl)[Cl:17].Cl>CN(C=O)C>[Cl:17][C:7]1[C:8]([OH:13])=[N:9][C:10]2[C:5]([N:6]=1)=[CH:4][C:3]([O:2][CH3:1])=[CH:12][CH:11]=2

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 24386Thionyl ChlorideHCID 178488026HCID 178488026, Verbindung

Produkt 1

HCID 178488023HCID 178488023, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
110 °C

Versuchsvorschrift

A solution (1.53 M) of 6-methoxyquinoxaline-2,3-diol in DMF was treated with SOCl2 (1 eq) and heated at 110° C. After 1.5 h, the reaction mixture was cooled and poured into aqueous HCl (1 N). The resulting precipitate was filtered and washed with H2O and Et2O. The dried solid contained predominantly the title compound as a mixture with 6-methoxyquinoxaline-2,3-diol and 2,3-dichloro-6-methoxyquinoxaline. This material was used directly in the subsequent step. MS (ES+) m/z 211 (M+H)+

Aufarbeitung

  1. temperaturethe reaction mixture was cooled
  2. filtrationThe resulting precipitate was filtered
  3. washwashed with H2O and Et2O

Quellen und Nachweise

ORD-Eintrag
ord-f68c3efe021647389423858c30b425de
Quelldatensatz
uspto-grants-2011_12
Patentnummer
US08080654B2

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