Hydrochloric Acid → Methyl (2S)-4-((3-chloro-7-methoxyquinoxalin-2-yl)oxy)pyrrolidine-2-carboxylate hydrochloride

HRID 659827Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 659827
[Cl:1][C:2]1[C:3]([O:14][C@H:15]2[CH2:19][N:18](C(OC(C)(C)C)=O)[C@H:17]([C:27]([O:29][CH3:30])=[O:28])[CH2:16]2)=[N:4][C:5]2[C:10]([N:11]=1)=[CH:9][CH:8]=[C:7]([O:12][CH3:13])[CH:6]=2.Cl.O1CCOCC1>C(Cl)Cl>[ClH:1].[Cl:1][C:2]1[C:3]([O:14][C@H:15]2[CH2:19][NH:18][C@H:17]([C:27]([O:29][CH3:30])=[O:28])[CH2:16]2)=[N:4][C:5]2[C:10]([N:11]=1)=[CH:9][CH:8]=[C:7]([O:12][CH3:13])[CH:6]=2

Komponenten

5

Edukt 3

HCID 313Hydrochloric Acid2×HCID 312751,4-Dioxane2×HCID 584284571-(tert-Butyl) 2-methyl (2S,4R)-4-((3-chloro-7-methoxyquinoxalin-2-yl)oxy)pyrrolidine-1,2-dicarboxylate

Produkt 1

HCID 78358295Methyl (2S)-4-((3-chloro-7-methoxyquinoxalin-2-yl)oxy)pyrrolidine-2-carboxylate hydrochlorideAusbeute 95 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Reaktionsbedingungen

Temperatur
20 °C

Versuchsvorschrift

A solution (0.62 M) of 1-tert-butyl 2-methyl (2S,4R)-4-[(3-chloro-7-methoxyquinoxalin-2-yl)oxy]pyrrolidine-1,2-dicarboxylate in CH2Cl2 was treated with a solution (4 M) of HCl in dioxane (5 eq). The mixture was stirred at 20° C. for 2 h, then treated with a solution (4 M) of HCl in dioxane (2 eq). After 5 h, the reaction was judged complete and the mixture was concentrated under reduced pressure. The residue was triturated with Et2O to give the title compound (95%) as a solid. MS (ES+) m/z 338 (M+H)+

Aufarbeitung

  1. waitAfter 5 h
  2. concentrationthe mixture was concentrated under reduced pressure
  3. customThe residue was triturated with Et2O

Quellen und Nachweise

ORD-Eintrag
ord-209cb44959954754a9acdb8ce4e119df
Quelldatensatz
uspto-grants-2011_12
Patentnummer
US08080654B2

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