Methylamine → HCID 70625931, Verbindung

HRID 65989Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 65989
[Cl:1][C:2]1[C:3]2[C:4](=[N:14][N:15]([CH3:17])[CH:16]=2)[N:5]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:7]=1.[CH3:18][NH2:19]>>[ClH:1].[CH3:18][NH:19][C:2]1[C:3]2[C:4](=[N:14][N:15]([CH3:17])[CH:16]=2)[N:5]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:7]=1.[CH3:18][N:14]1[C:4]2=[N:5][C:6]([C:8]3[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=3)=[CH:7][CH:2]=[C:3]2[CH2:16][N:15]1[CH3:17]

Komponenten

4

Edukt 2

HCID 6329MethylamineHCID 22756855HCID 22756855, Verbindung

Produkt 2

HCID 70625931HCID 70625931, VerbindungHCID 131710884HCID 131710884, Verbindung

Versuchsvorschrift

17 g. of 4-chloro-2-methyl-6-phenyl-2H-pyrazolo [3,4-b]pyridine (0.07 mol.) and 60 ml. of alcoholic methylamine (270 g/l) are heated at 150°-160° in an autoclave for four hours. After cooling to room temperature, the solution is evaporated in vacuo and the residue is extracted with chloroform. To the chloroform extract is added ethereal hydrochloric acid to give the crude hydrochloride of N,2-dimethyl-6-phenyl-2H-pyrazolo[3,4-b]pyridine which, after treatment with ether, becomes crystalline.

Aufarbeitung

  1. customthe solution is evaporated in vacuo
  2. extractionthe residue is extracted with chloroform
  3. extractionTo the chloroform extract
  4. additionis added ethereal hydrochloric acid

Quellen und Nachweise

ORD-Eintrag
ord-bcf835d3b3d24125adbc8e58bae80fc5
Quelldatensatz
uspto-grants-1978_12
Patentnummer
US04129738

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