Hydrogen Peroxide → 4-[2-(4-Fluoro-phenyl)-1,1-dimethoxy-ethyl]-pyridine 1-oxide

HRID 659949

Reaktionsgleichung

Reaktionsgleichung von HRID 659949
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([C:14]2[CH:19]=[CH:18][N:17]=[CH:16][CH:15]=2)([O:12][CH3:13])[O:10][CH3:11])=[CH:4][CH:3]=1.[OH:20]O>ClCCl.C[Re](=O)(=O)=O>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([C:14]2[CH:15]=[CH:16][N+:17]([O-:20])=[CH:18][CH:19]=2)([O:10][CH3:11])[O:12][CH3:13])=[CH:4][CH:3]=1

Komponenten

5

Edukt 2

HCID 784Hydrogen PeroxideHCID 149562264-[2-(4-Fluoro-phenyl)-1,1-dimethoxy-ethyl]-pyridine

Produkt 1

HCID 684293414-[2-(4-Fluoro-phenyl)-1,1-dimethoxy-ethyl]-pyridine 1-oxide

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178477782HCID 178477782, VerbindungKatalysatorHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

55 g (0.21 mole) of 4-[2-(4-Fluoro-phenyl)-1,1-dimethoxy-ethyl]-pyridine and 445 mg of methyltrioxorhenium are dissolved in 250 mL of dichloromethane. 112 mL of commercial hydrogen peroxide solution is added to the reaction mixture which is further stirred over night at room temperature. The reaction mixture is then decanted and the organic phase is washed with sodium hydrogen sulfate and water and dried over magnesium sulfate. After concentration, 33 g of 4-[2-(4-Fluoro-phenyl)-1,1-dimethoxy-ethyl]-pyridine 1-oxide is obtained as a green oil.

Aufarbeitung

  1. customThe reaction mixture is then decanted
  2. washthe organic phase is washed with sodium hydrogen sulfate and water
  3. dry with materialdried over magnesium sulfate
  4. concentrationAfter concentration

Quellen und Nachweise

ORD-Eintrag
ord-fae9c6c33f6a453e8bf832c89648a41c
Quelldatensatz
uspto-grants-2011_12
Patentnummer
US08084395B2

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