4-Chlorobenzylpiperazine → 2-(4'-p-Chlorobenzyl-piperazino)-5-oxo-6-carbethoxy-8-ethyl-5,8-dihydro-pyrido(2,3-d)pyrimidine

HRID 66009

Reaktionsgleichung

Reaktionsgleichung von HRID 66009
[Cl:1][C:2]1[CH:14]=[CH:13][C:5]([CH2:6][N:7]2[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)=[CH:4][CH:3]=1.Cl[C:16]1[N:17]=[CH:18][C:19]2[C:25](=[O:26])[C:24]([C:27]([O:29][CH2:30][CH3:31])=[O:28])=[CH:23][N:22]([CH2:32][CH3:33])[C:20]=2[N:21]=1>>[Cl:1][C:2]1[CH:14]=[CH:13][C:5]([CH2:6][N:7]2[CH2:12][CH2:11][N:10]([C:16]3[N:17]=[CH:18][C:19]4[C:25](=[O:26])[C:24]([C:27]([O:29][CH2:30][CH3:31])=[O:28])=[CH:23][N:22]([CH2:32][CH3:33])[C:20]=4[N:21]=3)[CH2:9][CH2:8]2)=[CH:4][CH:3]=1

Komponenten

3

Edukt 2

HCID 1348264-ChlorobenzylpiperazineHCID 122668052-Chloro-5-oxo-6-carbethoxy-8-ethyl-5,8-dihydropyrido(2,3-d)pyrimidine

Produkt 1

HCID 122668092-(4'-p-Chlorobenzyl-piperazino)-5-oxo-6-carbethoxy-8-ethyl-5,8-dihydro-pyrido(2,3-d)pyrimidineAusbeute 74 %

Versuchsvorschrift

Condensation of 1-p-chlorobenzyl-piperazine with 2-chloro-5-oxo-6-carbethoxy-8-ethyl-5,8-dihydro-pyrido(2,3-d)pyrimidine, as described in Example VII, gives, in a yield of 74%, 2-(4'-p-chlorobenzyl-piperazino)-5-oxo-6-carbethoxy-8-ethyl-5,8-dihydro-pyrido(2,3-d)pyrimidine; melting point 150° C., after recrystallisation from ethyl acetate.

Quellen und Nachweise

ORD-Eintrag
ord-52353e447c8043f5952fcb5206d578ee
Quelldatensatz
uspto-grants-1978_12
Patentnummer
US04129737

Verknüpfte Notizen

Wird geladen…