HCID 178442542, Verbindung → HCID 178442543, Verbindung
Reaktionsgleichung
[C:1]([C:8]1[C:9]([C:13]2[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=2)=[N:10][NH:11][CH:12]=1)#[C:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7].[CH3:19]SC1C(C2C=NC=CC=2)=NNC=1>>[C:1]([C:8]1[C:9]([C:13]2[CH2:14][N:15]([CH3:19])[CH2:16][CH2:17][CH:18]=2)=[N:10][NH:11][CH:12]=1)#[C:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7]Komponenten
3
Versuchsvorschrift
Compound 44B was converted to compound 45B, using the methodology described for the conversion of 21A to 22A (see Scheme 3). Yield: 44% (amorphous). LCMS (method A); Rt: 1.84 min, ([M+H]+=258). 1H-NMR (400 MHz, CDCl3): δ 7.57 (s, 1H), 6.78-6.66 (bs, 1H), 3.42-3.38 (m, 2H), 2.59 (bt, J=7 Hz, 2H), 2.45 (s, 3H), 2.44-2.37 (m, 2H), 1.62-1.43 (m, 4H), 0.94 (t, J=7 Hz, 3H).
Quellen und Nachweise
- ORD-Eintrag
- ord-e78ea86aed3545d4bceefca6f9d3a362
- Quelldatensatz
- uspto-grants-2011_12