Phosphorus oxychloride → Imidazo(1,5-a)pyridine

HRID 66018Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 66018
[CH:1]([NH:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][N:6]=1)=O.P(Cl)(Cl)(Cl)=O>>[CH:4]1[N:3]=[CH:1][N:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=12

Komponenten

3

Edukt 2

HCID 24813Phosphorus oxychlorideHCID 12228441N-Pyridin-2-ylmethyl-formamide

Produkt 1

HCID 274090Imidazo(1,5-a)pyridine

Versuchsvorschrift

To 13.6 g. of 2-formamidomethylpyridine in a round-bottom flask is added 25 ml. of phosphorous oxychloride. Following the exothermic reaction, the reaction mixture is cooled to room temperature, and quenched on crushed ice. The aqueous mixture is treated with sufficient 20% aqueous sodium hydroxide solution to provide a pH of 9-10, and the liberated product extracted into chloroform (3 × 300 ml.). The extracts are combined, dried over sodium sulfate and concentrated to a light brown oil, 14.0 g.

Aufarbeitung

  1. customthe exothermic reaction
  2. customquenched
  3. customon crushed ice
  4. additionThe aqueous mixture is treated with sufficient 20% aqueous sodium hydroxide solution
  5. customto provide a pH of 9-10
  6. extractionthe liberated product extracted into chloroform (3 × 300 ml.)
  7. dry with materialdried over sodium sulfate
  8. concentrationconcentrated to a light brown oil, 14.0 g

Quellen und Nachweise

ORD-Eintrag
ord-044094b8de884a8a986cf92efd096934
Quelldatensatz
uspto-grants-1978_12
Patentnummer
US04129567

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