HCID 57742139, Verbindung → HCID 12370790, Verbindung

HRID 660285Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 660285
[OH:1][C:2]1[CH:3]=[C:4]([CH:11]([CH3:17])[C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH:5]=[CH:6][C:7]=1[N+:8]([O-])=O>[C].[Pd].C1COCC1.CCO>[NH2:8][C:7]1[CH:6]=[CH:5][C:4]([CH:11]([CH3:17])[C:12]([O:14][CH2:15][CH3:16])=[O:13])=[CH:3][C:2]=1[OH:1]

Komponenten

4

Edukt 1

HCID 57742139HCID 57742139, Verbindung

Produkt 1

HCID 12370790HCID 12370790, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418390HCID 178418390, VerbindungKatalysatorHCID 21873804Tetrahydrofuran ethanolLösungsmittel

Versuchsvorschrift

To the flask was added THF/EtOH (1:1, 30 mL) followed by Ethyl 2-(3-hydroxy-4-nitrophenyl)propanoate (900 mg, 3.76 mmol) and 10% palladium carbon (93 mg) at room temperature. The reaction mixture was hydrogenated and stirred for 1 hrs at 46 psi then filtered through celite bed, and washed with EtOAc. The filtrate was concentrated in vacuo. The residue was purified by flash column chromatography on silica gel using EtOAc:hexanes (1:2) as eluant.

Aufarbeitung

  1. filtrationthen filtered through celite bed
  2. washwashed with EtOAc
  3. concentrationThe filtrate was concentrated in vacuo
  4. customThe residue was purified by flash column chromatography on silica gel

Quellen und Nachweise

ORD-Eintrag
ord-32cc5fc129034436b707186d0896cd03
Quelldatensatz
uspto-grants-2011_12
Patentnummer
US08084484B2

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