Hydrochloric Acid → Nitro-(3-oxo-1H,3H-benzo[de]isochromen-1-yl)-acetic Acid Methyl Ester

HRID 660579Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 660579
CO[C:3]([C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][C:13]=2[CH:15]=[O:16])[CH:8]=[CH:7][CH:6]=1)=[O:4].[CH3:17][O:18][C:19](=[O:24])[CH2:20][N+:21]([O-:23])=[O:22].C(OCC)(=O)C.Cl>CCO.N1CCCCC1>[CH3:17][O:18][C:19](=[O:24])[CH:20]([N+:21]([O-:23])=[O:22])[CH:15]1[C:13]2[C:14]3[C:9](=[CH:8][CH:7]=[CH:6][C:5]=3[C:3](=[O:4])[O:16]1)[CH:10]=[CH:11][CH:12]=2

Komponenten

7

Edukt 4

HCID 313Hydrochloric AcidHCID 8857Ethyl AcetateHCID 17206Methyl 2-nitroacetateHCID 349031Methyl 8-formylnaphthalene-1-carboxylate

Produkt 1

HCID 86632579Nitro-(3-oxo-1H,3H-benzo[de]isochromen-1-yl)-acetic Acid Methyl Ester

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 8082PiperidineKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

To a solution of 8-formylnaphthalene-1-carboxylic acid methyl ester (2.5 g, 11.68 mmol) in EtOH (20 mL) is added 8 drops of piperidine followed by nitroacetic acid methyl ester (2.78 g, 23.4 mmol) and the mixture is stirred at RT for 20 h. Ethyl acetate is added followed by 1N HCl. The resulting precipitate is filtered to give the title compound.

Aufarbeitung

  1. filtrationThe resulting precipitate is filtered

Quellen und Nachweise

ORD-Eintrag
ord-9c1c9066a5de4d7fb35bfb62bd785215
Quelldatensatz
uspto-grants-2011_12
Patentnummer
US08084448B2

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