4-Chlorobenzohydrazide → HCID 47133870, Verbindung

HRID 660838

Reaktionsgleichung

Reaktionsgleichung von HRID 660838
[Cl:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([NH:8][NH2:9])=[O:7])=[CH:4][CH:3]=1.[CH:12]1([N:15]=[C:16]=[O:17])[CH2:14][CH2:13]1>O1CCCC1>[Cl:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([NH:8][NH:9][C:16]([NH:15][CH:12]2[CH2:14][CH2:13]2)=[O:17])=[O:7])=[CH:4][CH:3]=1

Komponenten

4

Edukt 2

HCID 108164-ChlorobenzohydrazideHCID 637659Isocyanatocyclopropane

Produkt 1

HCID 47133870HCID 47133870, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel2×

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

Under an argon atmosphere, 4.00 g (23.4 mmol) of 4-chlorobenzoic acid hydrazide are placed in 50 ml tetrahydrofuran. 1.95 g (23.4 mmol) of cyclopropyl isocyanate, dissolved in 50 ml tetrahydrofuran, are added dropwise at 50° C., and the mixture further stirred overnight at 50° C. The solvent is evaporated in vacuo, diethyl ether is added to the residue and the solid formed is isolated and purified by filtration and further washing with diethyl ether. 5.92 g (ca. 100% of theory) of the target compound are thus obtained.

Aufarbeitung

  1. additionare added dropwise at 50° C.
  2. customThe solvent is evaporated in vacuo, diethyl ether
  3. additionis added to the residue
  4. customthe solid formed
  5. customis isolated
  6. filtrationpurified by filtration
  7. washfurther washing with diethyl ether
  8. custom5.92 g (ca. 100% of theory) of the target compound are thus obtained

Quellen und Nachweise

ORD-Eintrag
ord-814020fe38114f1f9d9dedf11305c678
Quelldatensatz
uspto-grants-2011_12
Patentnummer
US08084481B2

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