3-Chlorobenzohydrazide → HCID 47131865, Verbindung

HRID 660839

Reaktionsgleichung

Reaktionsgleichung von HRID 660839
[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][CH:11]=1)[C:5]([NH:7][NH2:8])=[O:6].[CH:12]1([N:15]=[C:16]=[O:17])[CH2:14][CH2:13]1>O1CCCC1>[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][CH:11]=1)[C:5]([NH:7][NH:8][C:16]([NH:15][CH:12]1[CH2:14][CH2:13]1)=[O:17])=[O:6]

Komponenten

4

Edukt 2

HCID 742893-ChlorobenzohydrazideHCID 637659Isocyanatocyclopropane

Produkt 1

HCID 47131865HCID 47131865, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel2×

Versuchsvorschrift

Under an argon atmosphere, 430 mg (2.52 mmol) of 3-chlorobenzoic acid hydrazide are placed in 6 ml tetrahydrofuran. 209 mg (2.52 mmol) of cyclopropyl isocyanate, dissolved in 2 ml tetrahydrofuran is added dropwise and further stirred overnight at room temperature. It is concentrated and purified by stirring the residue with diethyl ether, filtration, further washing with diethyl ether and drying in vacuo. 514 mg (80% of theory) of the target compound are thus obtained.

Aufarbeitung

  1. additionis added dropwise and further stirred overnight at room temperature
  2. concentrationIt is concentrated
  3. custompurified
  4. filtrationwith diethyl ether, filtration
  5. washfurther washing with diethyl ether
  6. customdrying in vacuo
  7. custom514 mg (80% of theory) of the target compound are thus obtained

Quellen und Nachweise

ORD-Eintrag
ord-c617a670b8b54eb2adcb26308e061f78
Quelldatensatz
uspto-grants-2011_12
Patentnummer
US08084481B2

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