Methanol → 5-(4-chlorophenyl)-1-cyclopropyl-1,3-dihydro-2H-imidazol-2-one
Reaktionsgleichung
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=O)[CH2:9][NH:10][C:11]([NH:13][CH:14]2[CH2:16][CH2:15]2)=[O:12])=[CH:4][CH:3]=1.CO>Cl>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:13]([CH:14]3[CH2:16][CH2:15]3)[C:11](=[O:12])[NH:10][CH:9]=2)=[CH:4][CH:3]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
1525 mg (6.035 mmol) of N-[2-(4-chlorophenyl)-2-oxoethyl]-N′-cyclopropylurea from Example 113A are suspended in 25 ml of concentrated hydrochloric acid, treated with 25 ml methanol and stirred for one hour at room temperature. The reaction mixture is evaporated to dryness and the residue purified by flash chromatography on silica gel (eluent: dichloromethane/methanol 100:1, then 50:1). 1300 mg (90% of theory) of the target compound are obtained.