Hydrochloric Acid → [4-(4-bromophenyl)-3-cyclopropyl-2-oxo-2,3-dihydro-1H-imidazol-1-yl]-acetic acid

HRID 660875Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 660875
C([O:3][C:4](=[O:22])[CH2:5][N:6]1[CH:10]=[C:9]([C:11]2[CH:16]=[CH:15][C:14]([Br:17])=[CH:13][CH:12]=2)[N:8]([CH:18]2[CH2:20][CH2:19]2)[C:7]1=[O:21])C.[OH-].[K+].Cl>CO>[Br:17][C:14]1[CH:15]=[CH:16][C:11]([C:9]2[N:8]([CH:18]3[CH2:20][CH2:19]3)[C:7](=[O:21])[N:6]([CH2:5][C:4]([OH:22])=[O:3])[CH:10]=2)=[CH:12][CH:13]=1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 58012242Ethyl [4-(4-bromophenyl)-3-cyclopropyl-2-oxo-2,3-dihydro-1H-imidazol-1-yl]-acetate

Produkt 1

HCID 58011674[4-(4-bromophenyl)-3-cyclopropyl-2-oxo-2,3-dihydro-1H-imidazol-1-yl]-acetic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

502 mg (1.28 mmol) of ethyl[4-(4-bromophenyl)-3-cyclopropyl-2-oxo-2,3-dihydro-1H-imidazol-1-yl]-acetate from Example 124A are placed in 0.94 ml methanol, treated with 0.34 ml 20% aqueous potassium hydroxide and stirred overnight at room temperature. It is adjusted to pH 3 with 1 N hydrochloric acid, the resulting precipitate recovered by filtration, and the product washed with water and dried in vacuo. 369 mg (80% of theory) of the target compound, which is reacted without further purification, are thus obtained.

Aufarbeitung

  1. filtrationthe resulting precipitate recovered by filtration
  2. washthe product washed with water
  3. customdried in vacuo
  4. custom369 mg (80% of theory) of the target compound, which is reacted without further purification
  5. customare thus obtained

Quellen und Nachweise

ORD-Eintrag
ord-99b319155a4349a5a56dc243f5c647cf
Quelldatensatz
uspto-grants-2011_12
Patentnummer
US08084481B2

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