Hydrazine → 3-Amino-5-bromo-1H-indazole
Reaktionsgleichung
[Br:1][C:2]1[CH:3]=[CH:4][C:5](F)=[C:6]([CH:9]=1)[C:7]#[N:8].[NH2:11][NH2:12]>>[Br:1][C:2]1[CH:9]=[C:6]2[C:5](=[CH:4][CH:3]=1)[NH:12][N:11]=[C:7]2[NH2:8]Komponenten
3
Reaktionsbedingungen
- Temperatur
- 100 °C
Versuchsvorschrift
To a 250 mL round-bottom flask was added 5-bromo-2-fluorobenzonitrile (15.54 g, 77.7 mmol) and hydrazine (124 g, 3885 mmol). The reaction mixture was heated to 100° C. for 5 minutes. The hydrazine was then removed under reduced pressure to give 5-bromo-1H-indazol-3-amine (16.4 g, 99.5% yield). MS m/z: 213 (M+1).
Aufarbeitung
- customThe hydrazine was then removed under reduced pressure
Quellen und Nachweise
- ORD-Eintrag
- ord-1aeeede6f2ab47b0aa89f0d2fed652e8
- Quelldatensatz
- uspto-grants-2011_12
- Patentnummer
- US08084479B2
Notizen zur Reaktion
Wird geladen…