Potassium Carbonate → 3-methoxy-N-[2-(3-methoxyphenyl)-ethyl]-N-propyl-benzene-ethanamine

HRID 66128Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 66128
Cl.[CH3:2][O:3][C:4]1[CH:5]=[C:6]([CH2:10][C:11]([NH:13][CH2:14][CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([O:22][CH3:23])[CH:17]=2)=O)[CH:7]=[CH:8][CH:9]=1.C(=O)([O-])[O-].[K+].[K+].[CH2:30](I)[CH2:31][CH3:32]>CC(C)=O>[CH3:2][O:3][C:4]1[CH:5]=[C:6]([CH2:10][CH2:11][N:13]([CH2:14][CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([O:22][CH3:23])[CH:17]=2)[CH2:30][CH2:31][CH3:32])[CH:7]=[CH:8][CH:9]=1

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 336431-IodopropaneHCID 227557503-methoxy-N-[2-(3-methoxyphenyl)-ethyl]-benzene-ethanamide hydrochloride

Produkt 1

HCID 124780053-methoxy-N-[2-(3-methoxyphenyl)-ethyl]-N-propyl-benzene-ethanamineAusbeute 97,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

A suspension of 8.75 g of the product of Step A, 17.5 g of calcined neutral potassium carbonate, 17.5 g of propyl iodide and 180 ml of acetone was refluxed for 61/2 hours under nitrogen and the mixture was then filtered. The filtrate was evaporated to dryness and the residue was taken up in ether. The ether solution was washed with water, dried and evaporated to dryness to obtain 8.3 g of 3-methoxy-N-[2-(3-methoxyphenyl)-ethyl]-N-propyl-benzene-ethanamine which was used as is for the next step.

Aufarbeitung

  1. temperaturewas refluxed for 61/2 hours under nitrogen
  2. filtrationthe mixture was then filtered
  3. customThe filtrate was evaporated to dryness
  4. washThe ether solution was washed with water
  5. customdried
  6. customevaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-5ee94f4a4866432ba586e76f53bf5f20
Quelldatensatz
uspto-grants-1978_12
Patentnummer
US04130658

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