Tetramethylammonium fluoride → (R)-2-(3,4-dichloro-benzoyl)-4-hydroxy-2-propyl-pyrrolidine-1-carboxylic acid tert-butyl ester
Reaktionsgleichung
[C:1]([O:5][C:6]([N:8]1[CH2:12][CH:11]([O:13][Si](C(C)(C)C)(C)C)[CH2:10][C@:9]1([CH2:31][CH2:32][CH3:33])[C:21](=[O:30])[C:22]1[CH:27]=[CH:26][C:25]([Cl:28])=[C:24]([Cl:29])[CH:23]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].C[N+](C)(C)C.[F-]>>[C:1]([O:5][C:6]([N:8]1[CH2:12][CH:11]([OH:13])[CH2:10][C@@:9]1([C:21](=[O:30])[C:22]1[CH:27]=[CH:26][C:25]([Cl:28])=[C:24]([Cl:29])[CH:23]=1)[CH2:31][CH2:32][CH3:33])=[O:7])([CH3:2])([CH3:3])[CH3:4]Komponenten
3
Versuchsvorschrift
(R)-2-(3,4-Dichloro-benzoyl)-4-hydroxy-2-propyl-pyrrolidine-1-carboxylic acid tert-butyl ester was prepared by treating (R)-4-(tert-Butyl-dimethyl-silanyloxy)-2-propyl-2-(3,4-dichloro-benzoyl)-pyrrolidine-1-carboxylic acid tert-butyl ester with TMAF following the procedure of step 3 of Example 11.