HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Sec-Butylamine → 2-(7-Chloro-1,8-naphthyridin-2-yl)-3-sec-butylaminocarbonyloxy-isoindolin-1-one
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Sec-Butylamine | HCID 24874 | — |
| Edukt | 2-(7-Chloro-1,8-naphthyridin-2-yl)-3-phenoxycarbonyloxy-1-isoindolinone | HCID 23343637 | — |
| Lösungsmittel | Diisopropyl Ether | HCID 7914 | — |
| Produkt | 2-(7-Chloro-1,8-naphthyridin-2-yl)-3-sec-butylaminocarbonyloxy-isoindolin-1-one | HCID 22754738 | — |
Reaktionsbedingungen
| Temperatur | 65 °C |
|---|
Reaktionsschritte
A mixture of 2-(7-chloro-1,8-naphthyridin-2-yl)-3-phenoxycarbonyloxy-isoindolin-1-one (8.6 g.) and sec-butylamine (40 cc.) is heated at 65° C. until dissolution. The reaction mixture is then diluted with diisopropyl ether (240 cc.). The precipitate formed is filtered off and recrystallised from acetonitrile (60 cc.). 2-(7-Chloro-1,8-naphthyridin-2-yl)-3-sec-butylaminocarbonyloxy-isoindolin-1-one (3 g.), melting at 220°-222° C., is thus obtained.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US04131674 |
| Quelldatensatz | uspto-grants-1978_12 |
| ORD ID | ord-023d2509928949a9bbadc17115bc650a |
| Quellennotiz | uspto-grants-1978_12 |