Nitric Acid → 3-Nitro-5-(trifluoromethyl)pyridin-2-ol

HRID 66364

Reaktionsgleichung

Reaktionsgleichung von HRID 66364
[N+:1]([O-:4])(O)=[O:2].[F:5][C:6]([F:15])([F:14])[C:7]1[CH:8]=[CH:9][C:10](=[O:13])[NH:11][CH:12]=1>>[N+:1]([C:9]1[C:10](=[O:13])[NH:11][CH:12]=[C:7]([C:6]([F:15])([F:5])[F:14])[CH:8]=1)([O-:4])=[O:2]

Komponenten

3

Edukt 2

HCID 944Nitric AcidHCID 1474432-Hydroxy-5-(trifluoromethyl)pyridine

Produkt 1

HCID 27750933-Nitro-5-(trifluoromethyl)pyridin-2-ol

Versuchsvorschrift

To 0.95 l. of stirred fuming nitric acid was added 29 g. of 5-trifluoromethyl-2-pyridone over 1 hour, and stirring was continued for 75 hours. The fuming nitric acid was evaporated and the residue was triturated with acetone. The acetone was evaporated to about 60 ml. and the precipitate was collected on a filter and washed with a 5:1 mixture of methylene chloride:acetone and dried and used directly in the next step.

Aufarbeitung

  1. customThe fuming nitric acid was evaporated
  2. customthe residue was triturated with acetone
  3. customThe acetone was evaporated to about 60 ml
  4. customand the precipitate was collected on
  5. filtrationa filter
  6. washwashed with a 5:1 mixture of methylene chloride
  7. dry with materialacetone and dried

Quellen und Nachweise

ORD-Eintrag
ord-4ef501ed967540b5aac24abf05f09fce
Quelldatensatz
uspto-grants-1978_12
Patentnummer
US04131677

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