Potassium Carbonate → HCID 13037298, Verbindung

HRID 66585

Reaktionsgleichung

Reaktionsgleichung von HRID 66585
[C:1]([C:4]1[CH:13]=[CH:12][CH:11]=[C:6]([C:7]([O:9][CH3:10])=[O:8])[C:5]=1[OH:14])(=[O:3])[CH3:2].C(=O)([O-])[O-].[K+].[K+].Br[CH:22]1[CH2:27][CH2:26][O:25][C:23]1=[O:24]>CC(C)=O>[C:1]([C:4]1[C:5]([O:14][CH:22]2[CH2:27][CH2:26][O:25][C:23]2=[O:24])=[C:6]([C:7]([O:9][CH3:10])=[O:8])[CH:11]=[CH:12][CH:13]=1)(=[O:3])[CH3:2]

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 954632(3H)-Furanone, 3-bromodihydro-HCID 13037297Methyl 3-acetyl-2-hydroxybenzoate

Produkt 1

HCID 13037298HCID 13037298, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

To a mixture of methyl 3-acetylsalicylate (5.8 g) and potassium carbonate (10.4 g) in acetone (200 ml) was added α-bromo-γ-butyrolactone (12.5 g) under stirring, and the mixture was refluxed for 11 hours. The insolubles were filtered off and the filtrate was concentrated under reduced pressure. The residue was subjected to chromatography on silica gel eluting with chloroform. By the above procedure, there was obtained α-[(6-acetyl-2-methoxycarbonylphenyl)oxy]-γ-butyrolactone as pale yellow oil.

Aufarbeitung

  1. temperaturethe mixture was refluxed for 11 hours
  2. filtrationThe insolubles were filtered off
  3. concentrationthe filtrate was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-6d6d16c133d14dc98d2670831a546e4a
Quelldatensatz
uspto-grants-1982_08
Patentnummer
US04342779

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