Hydrochloric Acid → 5-Hydroxy-5-(1-methyl-2-pyrrolyl)-2,4,6-(1H,3H,5H)pyrimidinetrione

HRID 66590

Reaktionsgleichung

Reaktionsgleichung von HRID 66590
O.[NH:2]1[C:10](=[O:11])[C:8](=[O:9])[C:6](=[O:7])[NH:5][C:3]1=[O:4].[CH3:12][N:13]1[CH:17]=[CH:16][CH:15]=[CH:14]1.Cl>C(O)C>[OH:9][C:8]1([C:14]2[N:13]([CH3:12])[CH:17]=[CH:16][CH:15]=2)[C:6](=[O:7])[NH:5][C:3](=[O:4])[NH:2][C:10]1=[O:11]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 73041-MethylpyrroleHCID 167232,4,5,6(1H,3H)-Pyrimidinetetrone, monohydrate

Produkt 1

HCID 212712485-Hydroxy-5-(1-methyl-2-pyrrolyl)-2,4,6-(1H,3H,5H)pyrimidinetrioneAusbeute 65 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

Alloxan hydrate (3.2 g., 0.02 mole) was dissolved in 50 ml. of ethanol by warming. 1-Methylpyrrole (1.6 g., 0.02 mole) was added and the mixture warmed for 5 minutes on a steam bath, while perfusing with hydrogen chloride. After standing at room temperature for 0.5 hour, the reaction mixture was evaporated to dryness and the residue triturated with water to yield title product as a solid [2.9 g.; m/e 223; Rf 0.5 (1:1 ethyl acetate:hexane/5% acetic acid)].

Aufarbeitung

  1. temperaturethe mixture warmed for 5 minutes on a steam bath
  2. customthe reaction mixture was evaporated to dryness
  3. customthe residue triturated with water

Quellen und Nachweise

ORD-Eintrag
ord-2676d5a2c28a47e1b6332256d52bbbbe
Quelldatensatz
uspto-grants-1982_08
Patentnummer
US04342771

Verknüpfte Notizen

Wird geladen…