HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Benzyl Bromide → 5-benzyloxy-3-phenyl-1H-2-indole-carboxylic acid ethylester
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Benzyl Bromide | HCID 7498 | — |
| Edukt | Potassium Carbonate | HCID 11430 | — |
| Edukt | Ethyl 5-hydroxy-3-phenyl-1H-indole-2-carboxylate | HCID 11550917 | — |
| Lösungsmittel | Methyl Ethyl Ketone | HCID 6569 | — |
| Produkt | 5-benzyloxy-3-phenyl-1H-2-indole-carboxylic acid ethylester | HCID 4777862 | — |
Reaktionsschritte
Twenty-six grams (92.4 m mole) of 5-hydroxy-3-phenyl-1H-2-indole carboxylic acid ethylester were refluxed for four days with 27.6 g of potassium carbonate and 11 ml (92.4 mole) of benzylbromide in 700 ml of methyl-ethylketone. After filtration and evaporation, the residue was chromatographed on silicagel (solvent: toluene).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US04343811 |
| Quelldatensatz | uspto-grants-1982_08 |
| ORD ID | ord-0cfe56dcc81144c48b41a140a5ebcfd0 |
| Quellennotiz | uspto-grants-1982_08 |