HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Toluene → 5-(2-Toluamido)-3-Trichloromethyl-1,2,4-Thiadiazole
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Toluene | HCID 1140 | — |
| Edukt | 2-Methylbenzoyl chloride | HCID 70276 | — |
| Edukt | 3-(Trichloromethyl)-1,2,4-thiadiazol-5-amine | HCID 602848 | — |
| Lösungsmittel | O-Xylene | HCID 7237 | — |
| Produkt | 5-(2-Toluamido)-3-Trichloromethyl-1,2,4-Thiadiazole | HCID 13041514 | 35,1% |
Reaktionsschritte
A solution of 22.0 g (0.1 mole) 5-amino-3-trichloromethyl-1,2,4-thiadiazole and 16.0 g (0.1 mole) 2-toluoyl chloride in 250 ml xylene was heated at reflux for 20 hours. The reaction mixture was cooled to room temperature and the resulting precipitate removed by filtration. Following recrystallization for toluene, 11.8 g (35% yield) of pure product was otained; m.p. 170° C.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US04343945 |
| Quelldatensatz | uspto-grants-1982_08 |
| ORD ID | ord-40e39dbc987749c18435765ac008b42e |
| Quellennotiz | uspto-grants-1982_08 |