p-Anisoyl chloride → 5-(4-Anisamido)-3-Trichloromethyl-1,2,4-Thiadiazole

HRID 66938

Reaktionsgleichung

Reaktionsgleichung von HRID 66938
[NH2:1][C:2]1[S:6][N:5]=[C:4]([C:7]([Cl:10])([Cl:9])[Cl:8])[N:3]=1.[C:11](Cl)(=[O:20])[C:12]1[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][CH:13]=1>C1(C)C(C)=CC=CC=1>[C:11]([NH:1][C:2]1[S:6][N:5]=[C:4]([C:7]([Cl:10])([Cl:9])[Cl:8])[N:3]=1)(=[O:20])[C:12]1[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][CH:13]=1

Komponenten

4

Edukt 2

HCID 7477p-Anisoyl chlorideHCID 6028483-(Trichloromethyl)-1,2,4-thiadiazol-5-amine

Produkt 1

HCID 130415175-(4-Anisamido)-3-Trichloromethyl-1,2,4-Thiadiazole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 7237O-XyleneLösungsmittel

Versuchsvorschrift

A solution of 11.0 g (0.05 mole) 5-amino-3-trichloromethyl-1,2,4-thiadiazole and 12.8 g (0.08 mole) 4-anisoyl chloride in 200 ml xylene was heated at reflux for 20 hours. Cooling of the reaction mixture resulted in precipitation of the crude product, which was then isolated by filtration. Purification was achieved by washing the crude product with hot hexane. Yield was 12.0 g (82%); m.p. 172° C.

Aufarbeitung

  1. temperatureat reflux for 20 hours
  2. temperatureCooling of the reaction mixture

Quellen und Nachweise

ORD-Eintrag
ord-c5e879964bea48bfb1cb9bbca35b987c
Quelldatensatz
uspto-grants-1982_08
Patentnummer
US04343945

Verknüpfte Notizen

Wird geladen…