4-Nitrobenzoyl chloride → 5-(4-Nitrobenzamido)-3-Trichloromethyl-1,2,4-Thiadiazole

HRID 66940Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 66940
[NH2:1][C:2]1[S:6][N:5]=[C:4]([C:7]([Cl:10])([Cl:9])[Cl:8])[N:3]=1.[N+:11]([C:14]1[CH:22]=[CH:21][C:17]([C:18](Cl)=[O:19])=[CH:16][CH:15]=1)([O-:13])=[O:12]>C1(C)C=CC=CC=1>[N+:11]([C:14]1[CH:15]=[CH:16][C:17]([C:18]([NH:1][C:2]2[S:6][N:5]=[C:4]([C:7]([Cl:10])([Cl:9])[Cl:8])[N:3]=2)=[O:19])=[CH:21][CH:22]=1)([O-:13])=[O:12]

Komponenten

4

Edukt 2

HCID 85024-Nitrobenzoyl chlorideHCID 6028483-(Trichloromethyl)-1,2,4-thiadiazol-5-amine

Produkt 1

HCID 130415195-(4-Nitrobenzamido)-3-Trichloromethyl-1,2,4-ThiadiazoleAusbeute 73,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

A solution of 10.9 g (0.05 mole) 5-amino-3-trichloromethyl-1,2,4-thiadiazole and 10.2 g (0.055 mole) 4-nitrobenzoyl chloride in 200 ml toluene was heated at reflux for 20 hours. Upon cooling to room temperature, the crude product precipitated from the reaction mixture and was isolated by filtration. After washing with hexane, 13.5 g (73% yield) of pure product was obtained; m.p. 214° C.

Aufarbeitung

  1. temperatureat reflux for 20 hours
  2. customthe crude product precipitated from the reaction mixture
  3. customwas isolated by filtration
  4. washAfter washing with hexane

Quellen und Nachweise

ORD-Eintrag
ord-cf535115d4a34be684be0052ae84a514
Quelldatensatz
uspto-grants-1982_08
Patentnummer
US04343945

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