2,4-Dichlorobenzoyl chloride → 5-(2,4-Dichlorobenzamido)-3-Trichloromethyl-1,2,4-Thiadiazole

HRID 66945Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 66945
[NH2:1][C:2]1[S:6][N:5]=[C:4]([C:7]([Cl:10])([Cl:9])[Cl:8])[N:3]=1.[Cl:11][C:12]1[CH:20]=[C:19]([Cl:21])[CH:18]=[CH:17][C:13]=1[C:14](Cl)=[O:15]>C1(C)C(C)=CC=CC=1>[Cl:11][C:12]1[CH:20]=[C:19]([Cl:21])[CH:18]=[CH:17][C:13]=1[C:14]([NH:1][C:2]1[S:6][N:5]=[C:4]([C:7]([Cl:10])([Cl:9])[Cl:8])[N:3]=1)=[O:15]

Komponenten

4

Edukt 2

HCID 666452,4-Dichlorobenzoyl chlorideHCID 6028483-(Trichloromethyl)-1,2,4-thiadiazol-5-amine

Produkt 1

HCID 130415245-(2,4-Dichlorobenzamido)-3-Trichloromethyl-1,2,4-ThiadiazoleAusbeute 69,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 7237O-XyleneLösungsmittel

Versuchsvorschrift

A solution of 10.9 g (0.05 mole) 5-amino-3-trichloromethyl-1,2,4-thiadiazole and 20.9 g (0.10 mole) 2,4-dichlorobenzoyl chloride was refluxed in 200 ml xylene for 20 hours. The reaction mixture was concentrated in vacuo and the resulting residue extracted with benzene. Addition of hexane resulted in precipitation of 13.6 g (69% yield) pure product; m.p. 136° C.

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. extractionthe resulting residue extracted with benzene
  3. additionAddition of hexane

Quellen und Nachweise

ORD-Eintrag
ord-5ed551a71a4646b6861ec463374c3df0
Quelldatensatz
uspto-grants-1982_08
Patentnummer
US04343945

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