Diethylamine → 2-(Diethylamino-acetylamino)6-amino-benzo[1,2-d:5,4-d']bisthiazole

HRID 67105

Reaktionsgleichung

Reaktionsgleichung von HRID 67105
Cl[CH2:2][C:3]([NH:5][C:6]1[S:7][C:8]2[C:9](=[CH:11][C:12]3[N:13]=[C:14]([NH2:18])[S:15][C:16]=3[CH:17]=2)[N:10]=1)=[O:4].[CH2:19]([NH:21][CH2:22][CH3:23])[CH3:20]>O1CCOCC1>[CH2:19]([N:21]([N:5]([C:3](=[O:4])[CH3:2])[C:6]1[S:7][C:8]2[C:9](=[CH:11][C:12]3[N:13]=[C:14]([NH2:18])[S:15][C:16]=3[CH:17]=2)[N:10]=1)[CH2:22][CH3:23])[CH3:20]

Komponenten

4

Edukt 2

HCID 8021DiethylamineHCID 205282012-Chloroacetylamino-6-amino-benzo[1,2-d:5,4-d']bisthiazole

Produkt 1

HCID 867385292-(Diethylamino-acetylamino)6-amino-benzo[1,2-d:5,4-d']bisthiazole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

A mixture of 0.5 gm of 2-(chloroacetyl-amino)-6-amino-benzo[1,2-d:5,4-d']bisthiazole, 0.7 gm of diethylamine and 3 ml of dioxane was refluxed for 2 hours. Then, the solvent was evaporated in vacuo, the residue was dissolved in ethyl acetate, and the solution was washed with water and dried over sodium sulfate. After evaporation of the solvent, 0.3 gm (60% of theory) of the title compound, M.P. 203°-205° C. (from ethanol/dimethylformamide) were obtained.

Aufarbeitung

  1. temperaturewas refluxed for 2 hours
  2. customThen, the solvent was evaporated in vacuo
  3. dissolutionthe residue was dissolved in ethyl acetate
  4. washthe solution was washed with water
  5. dry with materialdried over sodium sulfate
  6. customAfter evaporation of the solvent, 0.3 gm (60% of theory) of the title compound
  7. customM.P. 203°-205° C. (from ethanol/dimethylformamide) were obtained

Quellen und Nachweise

ORD-Eintrag
ord-cce5813548c3422aa236ff55eaeacd1a
Quelldatensatz
uspto-grants-1982_08
Patentnummer
US04344946

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