Ethanethiol → 3-[(4-Hydroxyphenyl)methyl]glutaric acid

HRID 67204

Reaktionsgleichung

Reaktionsgleichung von HRID 67204
C(S)C.C[O:5][C:6]1[CH:11]=[CH:10][C:9]([CH2:12][CH:13]([CH2:18][C:19]([OH:21])=[O:20])[CH2:14][C:15]([OH:17])=[O:16])=[CH:8][CH:7]=1>CN(C)C=O>[OH:5][C:6]1[CH:11]=[CH:10][C:9]([CH2:12][CH:13]([CH2:18][C:19]([OH:21])=[O:20])[CH2:14][C:15]([OH:17])=[O:16])=[CH:8][CH:7]=1

Komponenten

4

Edukt 2

HCID 6343EthanethiolHCID 205288313-[(4-Methoxyphenyl)methyl]glutaric acid

Produkt 1

HCID 205288373-[(4-Hydroxyphenyl)methyl]glutaric acidAusbeute 79,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel3×

Reaktionsbedingungen

Temperatur
165 °C

Versuchsvorschrift

To a stirred suspension of 57% sodium hydride-paraffin (1.4 g) in dry dimethylformamide (30 ml) is added dropwise a solution of ethanethiol (4.0 ml) in dry dimethylformamide (10 ml). After 15 minutes, a solution of 3-[(4-methoxyphenyl)methyl]glutaric acid (800 mg) in dry dimethylformamide (20 ml) is added. The resulting slurry is heated in a bath at 165° C. for 20 hours and evaporated in vacuo. The residue is acidified with 20% hydrochloric acid, extracted with ether and the extracts are discarded. The aqueous solution is saturated with salt and extracted with ethyl acetate. The extracts are combined, washed once with brine, dried, evaporated and the residue crystallized from a mixture of ethyl acetate-chloroform-hexane to give 600 mg of 3-[(4-hydroxyphenyl)methyl]glutaric acid, melting point 117°-119° C.

Aufarbeitung

  1. customevaporated in vacuo
  2. extractionextracted with ether
  3. extractionextracted with ethyl acetate
  4. washwashed once with brine
  5. customdried
  6. customevaporated
  7. customthe residue crystallized from a mixture of ethyl acetate-chloroform-hexane

Quellen und Nachweise

ORD-Eintrag
ord-183362f4d89f475c9a0fe79a64f7faa3
Quelldatensatz
uspto-grants-1982_08
Patentnummer
US04345096

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