2-Bromo-1,2-diphenylethan-1-one → 2,3,5,6,7,8-Hexahydro-2,3-diphenylthiazolo[3,2-a][1,3]diazepin-3-ol hydrobromide

HRID 67230

Reaktionsgleichung

Reaktionsgleichung von HRID 67230
[NH:1]1[CH2:7][CH2:6][CH2:5][CH2:4][NH:3][C:2]1=[S:8].[Br:9][CH:10]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[C:11]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:12]>CC(C)=O>[BrH:9].[C:19]1([CH:10]2[S:8][C:2]3=[N:3][CH2:4][CH2:5][CH2:6][CH2:7][N:1]3[C:11]2([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[OH:12])[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1

Komponenten

4

Edukt 2

HCID 1026302-Bromo-1,2-diphenylethan-1-oneHCID 7365891,3-Diazepane-2-thione

Produkt 1

HCID 205282882,3,5,6,7,8-Hexahydro-2,3-diphenylthiazolo[3,2-a][1,3]diazepin-3-ol hydrobromide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

A 2.6 g. portion of hexahydro-2H-1,3-diazepin-2-thione is dissolved in 150 ml. of acetone and clarified. A 5.5 g. portion of 2-bromo-2-phenylacetophenone is added and the solution is refluxed for one hour and then stirred at room temperature for 16 hours. The solid is collected, washed with acetone and dried in vacuo at 60° C., giving 6.5 g. of the desired product, m.p. 195°-197° C. (dec.).

Aufarbeitung

  1. temperaturethe solution is refluxed for one hour
  2. customThe solid is collected
  3. washwashed with acetone
  4. customdried in vacuo at 60° C.
  5. customgiving 6.5 g

Quellen und Nachweise

ORD-Eintrag
ord-a3c634d5fec74401a80367e4f62dcb78
Quelldatensatz
uspto-grants-1982_08
Patentnummer
US04344954

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