Sodium Hydroxide → N-(2-Mercapto-3-methoxybenzoyl)-N-cyclopentylglycine

HRID 67902Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 67902
C([S:4][C:5]1[C:22]([O:23][CH3:24])=[CH:21][CH:20]=[CH:19][C:6]=1[C:7]([N:9]([CH:14]1[CH2:18][CH2:17][CH2:16][CH2:15]1)[CH2:10][C:11]([OH:13])=[O:12])=[O:8])(=O)C.[OH-].[Na+]>>[SH:4][C:5]1[C:22]([O:23][CH3:24])=[CH:21][CH:20]=[CH:19][C:6]=1[C:7]([N:9]([CH:14]1[CH2:18][CH2:17][CH2:16][CH2:15]1)[CH2:10][C:11]([OH:13])=[O:12])=[O:8]

Komponenten

3

Edukt 2

HCID 14798Sodium HydroxideHCID 20465214N-(2-Acetylthio-3-methoxybenzoyl)-N-cyclopentylglycine

Produkt 1

HCID 13599182N-(2-Mercapto-3-methoxybenzoyl)-N-cyclopentylglycine

Versuchsvorschrift

N-(2-Acetylthio-3-methoxybenzoyl)-N-cyclopentylglycine (4.4 g, 12.5 mmol) was stirred with excess sodium hydroxide solution for 2 hours at 25° C., then acidified and extracted with ethyl acetate. The extract was washed with water and brine, then dried and concentrated. The amorphous product was obtained by column chromatography of the residue.

Aufarbeitung

  1. extractionextracted with ethyl acetate
  2. washThe extract was washed with water and brine
  3. customdried
  4. concentrationconcentrated
  5. customThe amorphous product was obtained by column chromatography of the residue

Quellen und Nachweise

ORD-Eintrag
ord-06fc99b3ff9c4afea70f520bb5daf6ae
Quelldatensatz
uspto-grants-1982_08
Patentnummer
US04347246

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