1,7-Heptanediamine → HCID 178433306, Verbindung

HRID 67913

Reaktionsgleichung

Reaktionsgleichung von HRID 67913
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][NH2:9].[C:10]([NH:12][C:13](=[N:16][CH2:17][CH2:18][S:19][CH2:20][C:21]1[NH:25][CH:24]=[N:23][C:22]=1[CH3:26])SC)#[N:11]>>[C:10]([NH:12][C:13]([NH:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][NH2:9])=[N:16][CH2:17][CH2:18][S:19][CH2:20][C:21]1[NH:25][CH:24]=[N:23][C:22]=1[CH3:26])#[N:11]

Komponenten

3

Edukt 2

HCID 695331,7-HeptanediamineHCID 178503877HCID 178503877, Verbindung

Produkt 1

HCID 178433306HCID 178433306, VerbindungAusbeute 30,8 %

Versuchsvorschrift

1,7-Diaminoheptane (5.2 g) was warmed gently until molten and to it was added N-cyano-N'-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]-S-methylisothiourea (2.69 g). After stirring for 15 hours at room temperature the reaction mixture was extracted with ether to remove excess of the diamine starting material and then purified on a silica gel chromatographic column, eluting with isopropanol to give the title compound (1.08 g), m.p. 84°-87° C.

Aufarbeitung

  1. extractionwas extracted with ether
  2. customto remove excess of the diamine starting material
  3. custompurified on a silica gel chromatographic column
  4. washeluting with isopropanol

Quellen und Nachweise

ORD-Eintrag
ord-132f23205d9f4f4fa83e485dc18d90d4
Quelldatensatz
uspto-grants-1982_08
Patentnummer
US04347250

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