Piperidine → HCID 2804025, Verbindung

HRID 6793Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 6793
[F:1][C:2]([F:18])([F:17])[C:3]1[CH:4]=[C:5]([C:13]#[C:14][CH2:15]Br)[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1.[NH:19]1[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1.C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[F:1][C:2]([F:18])([F:17])[C:3]1[CH:4]=[C:5]([C:13]#[C:14][CH2:15][N:19]2[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]2)[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1

Komponenten

5

Edukt 3

HCID 8082PiperidineHCID 11430Potassium CarbonateHCID 2779977HCID 2779977, Verbindung

Produkt 1

HCID 2804025HCID 2804025, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

A mixture of 1-(3,5-bistrifluoromethylphenyl)-3-bromoprop-1-yne (2.53 g), piperidine (5 ml) and anhydrous potassium carbonate (5 g) in dry acetone (50 ml) was heated at reflux with stirring for 18 h. Removal of the solvent under reduced pressure and distillation of the residue under reduced pressure gave 2.26 g of an oil of boiling point 95° C./0.025 mm Hg.

Aufarbeitung

  1. temperaturewas heated
  2. temperatureat reflux
  3. customRemoval of the solvent
  4. distillationunder reduced pressure and distillation of the residue under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-02f0b0daf7f34f13804f67028ba672a7
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07084158B2

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