1,3-Dichloroacetone → HCID 178479412, Verbindung
Reaktionsgleichung
[C:1]([NH:4][C:5]([NH2:7])=[S:6])(=[NH:3])[NH2:2].[Cl:8][CH2:9][C:10]([CH2:12]Cl)=O>CC(C)=O>[ClH:8].[NH:4]([C:5]1[S:6][CH:12]=[C:10]([CH2:9][Cl:8])[N:7]=1)[C:1]([NH2:2])=[NH:3]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
A suspension of amidinothiourea (16.8 g.) in acetone (75 ml.) was treated with 1,3-dichloroacetone (18 g.) in acetone (60 ml.). There was a slight exotherm and the crystalline suspension gradually changed to a fine white solid. After stirring overnight at room temperature the solid was filtered off and washed with acetone. Crystallization from ethanol gave 2-guanidino-4-chloromethylthiazole hydrochloride, m.p. 191°-193° C.
Aufarbeitung
- filtrationwas filtered off
- washwashed with acetone
- customCrystallization from ethanol
Quellen und Nachweise
- ORD-Eintrag
- ord-8f0590970f954d00939dac7949961f7e
- Quelldatensatz
- uspto-grants-1982_08
- Patentnummer
- US04347370
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