Potassium Carbonate → Tert-butyl 2-(2-bromo-4-formylphenoxy)acetate

HRID 68584

Reaktionsgleichung

Reaktionsgleichung von HRID 68584
[Br:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[OH:10])[CH:5]=[O:6].C(=O)([O-])[O-].[K+].[K+].Br[CH2:18][C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20]>CC(C)=O>[Br:1][C:2]1[CH:3]=[C:4]([CH:5]=[O:6])[CH:7]=[CH:8][C:9]=1[O:10][CH2:18][C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20]

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 763083-Bromo-4-hydroxybenzaldehydeHCID 79177tert-Butyl bromoacetate

Produkt 1

HCID 17999215Tert-butyl 2-(2-bromo-4-formylphenoxy)acetateAusbeute 951,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

To a solution of 3-bromo-4-hydroxybenzaldehyde (100 g, 50 mol, 1 eq) in acetone (500 mL) was added potassium carbonate (135 g, 100 mmol, 2 eq) followed by t-butyl 2-bromoacetate (100 g, 50 mmol, 1 eq). After stirring at room temperature for 2 h, the acetone was removed in vacuo and the resultant residue was washed with water to give 150 g (89%) of t-butyl 2-(2-bromo-4-formylphenoxy)acetate (1).

Aufarbeitung

  1. customthe acetone was removed in vacuo
  2. washthe resultant residue was washed with water

Quellen und Nachweise

ORD-Eintrag
ord-53c9217a3475467587c1b302503c9848
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08822467B2

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