4-(Diethoxymethyl)benzaldehyde → 1-[4-(diethoxymethyl)phenyl]-N-[(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)methyl]methanamine

HRID 68633

Reaktionsgleichung

Reaktionsgleichung von HRID 68633
[CH2:1]([O:3][CH:4]([O:13][CH2:14][CH3:15])[C:5]1[CH:12]=[CH:11][C:8]([CH:9]=O)=[CH:7][CH:6]=1)[CH3:2].C[Si](C)(C)CCOCN1C=CN=C1C=O.[CH3:31][Si:32]([CH3:45])([CH3:44])[CH2:33][CH2:34][O:35][CH2:36][N:37]1[CH:41]=[CH:40][N:39]=[C:38]1[CH2:42][NH2:43]>>[CH2:1]([O:3][CH:4]([O:13][CH2:14][CH3:15])[C:5]1[CH:12]=[CH:11][C:8]([CH2:9][NH:43][CH2:42][C:38]2[N:37]([CH2:36][O:35][CH2:34][CH2:33][Si:32]([CH3:45])([CH3:44])[CH3:31])[CH:41]=[CH:40][N:39]=2)=[CH:7][CH:6]=1)[CH3:2]

Komponenten

4

Edukt 3

HCID 5959934-(Diethoxymethyl)benzaldehydeHCID 136002351-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carbaldehydeHCID 21918674(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-2-yl)methanamine

Produkt 1

HCID 671649171-[4-(diethoxymethyl)phenyl]-N-[(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)methyl]methanamine

Versuchsvorschrift

The same procedure as a series of reactions of Example 1, except that 4-(diethoxymethyl)benzaldehyde was used in place of 1-({[2-(trimethylsilyl)ethyloxy]methyl}-1H-imidazole-2-carboaldehyde and 1-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)methaneamine was used in place of {[4-(methyloxy)phenyl]methyl}amine, to obtain the title compound having the following physical properties.

Quellen und Nachweise

ORD-Eintrag
ord-4108ac9d6f874fd58af40e75bd2ec788
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08822459B2

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