Hydrogen Peroxide → HCID 136386276, Verbindung

HRID 68699

Reaktionsgleichung

Reaktionsgleichung von HRID 68699
[CH2:1]([C:3]1[C:11]2[C:6](=[CH:7][C:8](B(O)O)=[CH:9][CH:10]=2)[N:5]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[N:4]=1)[CH3:2].[OH:21]O>C(OCC)(=O)C>[CH2:1]([C:3]1[C:11]2[C:6](=[CH:7][C:8]([OH:21])=[CH:9][CH:10]=2)[N:5]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[N:4]=1)[CH3:2]

Komponenten

4

Edukt 2

HCID 784Hydrogen PeroxideHCID 674485553-ethyl-1-phenyl-1H-indazol-6-ylboronic acid

Produkt 1

HCID 136386276HCID 136386276, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

Into a 50-mL round-bottom flask, was placed a solution of 3-ethyl-1-phenyl-1H-indazol-6-ylboronic acid (1.4 g, 5.26 mmol, 1.00 equiv) in ethyl acetate (10 mL). To the resulting mixture was then added H2O2 (2 mL) dropwise with stirring at 0° C. The resulting solution was stirred for 2 h at 0° C. in a water/ice bath. The resulting mixture was concentrated under vacuum. The residue was applied onto a silica gel column with ethyl acetate/petroleum ether (1:10) to yield 3-ethyl-1-phenyl-1H-indazol-6-ol as a white solid. MS: 239 (MH+).

Aufarbeitung

  1. customInto a 50-mL round-bottom flask, was placed
  2. concentrationThe resulting mixture was concentrated under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-c48c154d24654ca6bf097e1aea3e9b1d
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08822447B2

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