2-Bromopropanedial → 2-(4-Methylpyridin-2-ylamino)-thiazole-5-carbaldehyde

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

A mixture of (4-methylpyridin-2-yl)-thiourea (334 mg, 2 mmol), 2-bromomalonaldehyde (302 mg, 2 mmol) and sodium acetate (250 mg, 3.0 mmol) in acetic acid (5 mL) was stirred at 100° C. for 3 h. The mixture was cooled to RT and diluted with water and the precipitate formed was collected, washed with water and dried to afford 2-(4-methylpyridin-2-ylamino)-thiazole-5-carbaldehyde (350 mg, 80%). MS m/z 220 (M+H)+.

Herkunft & Nachweise