Sodium Hydroxide → 4-(4-Methyloxazol-5-yl)benzoic acid

HRID 68761Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 68761
C[O:2][C:3](=[O:16])[C:4]1[CH:9]=[CH:8][C:7]([C:10]2[O:14][CH:13]=[N:12][C:11]=2[CH3:15])=[CH:6][CH:5]=1.[OH-].[Na+]>CO>[CH3:15][C:11]1[N:12]=[CH:13][O:14][C:10]=1[C:7]1[CH:8]=[CH:9][C:4]([C:3]([OH:16])=[O:2])=[CH:5][CH:6]=1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 682895774-(4-Methyl-oxazol-5-yl)-benzoic acid methyl ester

Produkt 1

HCID 682900554-(4-Methyloxazol-5-yl)benzoic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of 4-(4-methyl-oxazol-5-yl)-benzoic acid methyl ester (1.50 g), 1 M aqueous NaOH solution (7.00 mL) and methanol (20 mL) is kept at room temperature overnight. The precipitate is filtered off, dissolved in water and neutralized with 4 M HCl. The precipitate is filtered off, dissolved in dichloromethane and a small amount of methanol, and the solution is dried over Na2SO4 and concentrated in vacuo. The residue is triturated with diethylether to afford the title compound. Mass spectrum (ESI+): m/z=204 [M+H]+.

Aufarbeitung

  1. filtrationThe precipitate is filtered off
  2. dissolutiondissolved in water and neutralized with 4 M HCl
  3. filtrationThe precipitate is filtered off
  4. dissolutiondissolved in dichloromethane
  5. dry with materiala small amount of methanol, and the solution is dried over Na2SO4
  6. concentrationconcentrated in vacuo
  7. customThe residue is triturated with diethylether

Quellen und Nachweise

ORD-Eintrag
ord-5bd8e7b8bd6e406aaeec05900acc07b0
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08822471B2

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