HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
N-cyclopropyl-4-fluoro-3-nitrobenzenesulfonamide → 3-amino-N-cyclopropyl-4-fluorobenzene-1-sulfonamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | N-cyclopropyl-4-fluoro-3-nitrobenzenesulfonamide | HCID 8469273 | — |
| Katalysator | Palladium | HCID 23938 | — |
| Lösungsmittel | Ethanol | HCID 702 | — |
| Produkt | 3-amino-N-cyclopropyl-4-fluorobenzene-1-sulfonamide | HCID 22019122 | 95,5% |
Reaktionsschritte
The mixture of N-cyclopropyl-4-fluoro-3-nitrobenzenesulfonamide (520 mg, 2 mmol) and Pd/C (10%, 100 mg) in EtOH was hydrogenated (1 atm) overnight. The mixture was filtered through a short pad of celite and concentrated in vacuo to afford N-cyclopropyl-4-fluoro-3-aminobenzenesulfonamide (440 mg, 95%) as an ivory solid. LC/MS; (M+H)+=231.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07084160B2 |
| Quelldatensatz | uspto-grants-2006_08 |
| ORD ID | ord-742bd07a01d3417fa9f833046b9b7c41 |
| Quellennotiz | uspto-grants-2006_08 |