N-cyclopropyl-4-fluoro-3-nitrobenzenesulfonamide → 3-amino-N-cyclopropyl-4-fluorobenzene-1-sulfonamide

HRID 6883

Reaktionsgleichung

Reaktionsgleichung von HRID 6883
[CH:1]1([NH:4][S:5]([C:8]2[CH:13]=[CH:12][C:11]([F:14])=[C:10]([N+:15]([O-])=O)[CH:9]=2)(=[O:7])=[O:6])[CH2:3][CH2:2]1>CCO.[Pd]>[CH:1]1([NH:4][S:5]([C:8]2[CH:13]=[CH:12][C:11]([F:14])=[C:10]([NH2:15])[CH:9]=2)(=[O:7])=[O:6])[CH2:3][CH2:2]1

Komponenten

4

Edukt 1

HCID 8469273N-cyclopropyl-4-fluoro-3-nitrobenzenesulfonamide

Produkt 1

HCID 220191223-amino-N-cyclopropyl-4-fluorobenzene-1-sulfonamideAusbeute 95,5 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

The mixture of N-cyclopropyl-4-fluoro-3-nitrobenzenesulfonamide (520 mg, 2 mmol) and Pd/C (10%, 100 mg) in EtOH was hydrogenated (1 atm) overnight. The mixture was filtered through a short pad of celite and concentrated in vacuo to afford N-cyclopropyl-4-fluoro-3-aminobenzenesulfonamide (440 mg, 95%) as an ivory solid. LC/MS; (M+H)+=231.

Aufarbeitung

  1. custom(1 atm) overnight
  2. filtrationThe mixture was filtered through a short pad of celite
  3. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-742bd07a01d3417fa9f833046b9b7c41
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07084160B2

Verknüpfte Notizen

Wird geladen…