1-Bromo-4-(methylsulphonyl)benzene → tert-butyl (2R)-2-methyl-4-(4-methylsulfonylphenyl)piperazine-1-carboxylate

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	1-Bromo-4-(methylsulphonyl)benzene	HCID 77014	—
Edukt	tert-Butyl (2R)-2-methylpiperazine-1-carboxylate	HCID 10262201	—
Reagenz	Potassium tert-butoxide	HCID 23665647	—
Katalysator	Tris(1,1-dimethylethyl)phosphine	HCID 83681	—
Katalysator	Bis(tri-tert-butylphosphine)palladium(0)	HCID 2734558	—
Lösungsmittel	1,4-Dioxane	HCID 31275	—
Produkt	tert-butyl (2R)-2-methyl-4-(4-methylsulfonylphenyl)piperazine-1-carboxylate	HCID 133499578	0%

Reaktionsbedingungen

Temperatur	100 °C

Reaktionsschritte

13-May-09 10:32:28 +0100 1-bromo-4-(methylsulfonyl)benzene (515 mg, 2.13 mmol), (R)-tert-butyl 2-methylpiperazine-1-carboxylate (426 mg, 2.13 mmol) and BIS(TRI-T- BUTYLPHOSPHINE)PALLADIUM(0) (54.3 mg, 0.11 mmol) and potassium 2-methylpropan-2-olate (352 mg, 2.98 mmol) were suspended in dioxane (10 mL) and heated to 90°C for 3 hours. LC-MS shows starting material. Reaction abandoned.

Herkunft & Nachweise

Quelldatensatz	750 AstraZeneca ELN dataset
ORD ID	ord-8f20cf3b966d4cdd9e1178539b8e969e
Quellennotiz	750 AstraZeneca ELN dataset