4-Nitro-3-(2-pyrrolidin-1-yl-ethylamino)-benzoic acid methyl ester → HCID 57917314, Verbindung

HRID 69142Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 69142
[CH3:1][O:2][C:3](=[O:21])[C:4]1[CH:9]=[CH:8][C:7]([N+:10]([O-])=O)=[C:6]([NH:13][CH2:14][CH2:15][N:16]2[CH2:20][CH2:19][CH2:18][CH2:17]2)[CH:5]=1>CO.C1COCC1.[Ni]>[CH3:1][O:2][C:3](=[O:21])[C:4]1[CH:9]=[CH:8][C:7]([NH2:10])=[C:6]([NH:13][CH2:14][CH2:15][N:16]2[CH2:20][CH2:19][CH2:18][CH2:17]2)[CH:5]=1

Komponenten

4

Edukt 1

HCID 579173564-Nitro-3-(2-pyrrolidin-1-yl-ethylamino)-benzoic acid methyl ester

Produkt 1

HCID 57917314HCID 57917314, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 21899815MeOH tetrahydrofuranLösungsmittel

Versuchsvorschrift

4-Nitro-3-(2-pyrrolidin-1-yl-ethylamino)-benzoic acid methyl ester (xiii) (1.30 g, 4.42 mmol) was shaken in MeOH/THF 1:1 (40 mL) in presence of Raney nickel under 1.1 bar H2 at rt for 40 min. The catalyst was filtered off and washed with MeOH. The filtrate was evaporated to give the title compound as an oil (tR 2.05 min (conditions 8), MH+=264).

Aufarbeitung

  1. filtrationThe catalyst was filtered off
  2. washwashed with MeOH
  3. customThe filtrate was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-f5692c16fcfe4d2895f31b62da87a115
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08822468B2

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