{4-[3-(7-Fluoro-quinolin-6-ylmethyl)-imidazo[1,2-b]pyridazin-6-yl]-pyrazol-1-yl}-acetonitrile → {4-[3-(5,7-Difluoro-quinolin-6-ylmethyl)-imidazo[1,2-b]pyridazin-6-yl]-pyrazol-1-yl}-acetonitrile
Reaktionsgleichung
[F:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][CH:8]=[N:9]2)=[CH:4][C:3]=1[CH2:12][C:13]1[N:17]2[N:18]=[C:19]([C:22]3[CH:23]=[N:24][N:25]([CH2:27][C:28]#[N:29])[CH:26]=3)[CH:20]=[CH:21][C:16]2=[N:15][CH:14]=1.[F:30]C1C(CC2N3N=C(C4C=NNC=4)C=CC3=NC=2)=C(F)C=C2C=1C=CC=N2>>[F:30][C:4]1[C:3]([CH2:12][C:13]2[N:17]3[N:18]=[C:19]([C:22]4[CH:23]=[N:24][N:25]([CH2:27][C:28]#[N:29])[CH:26]=4)[CH:20]=[CH:21][C:16]3=[N:15][CH:14]=2)=[C:2]([F:1])[CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][CH:8]=[N:9]2Komponenten
3
Edukt 2
Produkt 1
Versuchsvorschrift
The title compound was prepared in analogy to the compound of Example 176 using 5,7-difluoro-6-[6-(1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-ylmethyl]-quinoline (Example 263) instead of 6-(6-chloro-imidazo[1,2-b]pyridazin-3-ylmethyl)-7-fluoro-quinoline (tR 3.28 min (conditions 13), MH+=402).