4-Methyl-5-(4-methyl-piperazine-1-sulfonyl)-thiazol-2-ylamine → 7-Difluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid [4-methyl-5-(4-methyl-piperazine-1-sulfonyl)-thiazol-2-yl]-amide

Reaktionsgleichung

[CH3:26][c:27]1[n:28][c:29]([NH2:42])[s:30][c:31]1[S:32](=[O:33])(=[O:34])[N:35]1[CH2:36][CH2:37][N:38]([CH3:41])[CH2:39][CH2:40]1.[F:1][CH:2]([c:3]1[cH:4][c:5](-[c:15]2[cH:16][cH:17][c:18]([C:21]([F:22])([F:23])[F:24])[cH:19][cH:20]2)[n:6][c:7]2[n:8]1[n:9][cH:10][c:11]2[C:12](=[O:13])[OH:14])[F:25]>>[F:1][CH:2]([c:3]1[cH:4][c:5](-[c:15]2[cH:16][cH:17][c:18]([C:21]([F:22])([F:23])[F:24])[cH:19][cH:20]2)[n:6][c:7]2[n:8]1[n:9][cH:10][c:11]2[C:12](=[O:13])[NH:42][c:29]1[n:28][c:27]([CH3:26])[c:31]([S:32](=[O:33])(=[O:34])[N:35]2[CH2:36][CH2:37][N:38]([CH3:41])[CH2:39][CH2:40]2)[s:30]1)[F:25]