HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Hydrogen Bromide → 2-[(S)-4-(2,7-diaza-spiro[4.4]non-2-yl)-phenyl]-6-hydroxy-2H-isoquinolin-1-one
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Hydrogen Bromide | HCID 260 | — |
| Edukt | (S)-7-[4-(6-methoxy-1-oxo-1H-isoquinolin-2-yl)-phenyl]-2,7-diaza-spiro[4.4]nonane-2-carboxylic acid tert-butyl ester | HCID 68991895 | — |
| Produkt | 2-[(S)-4-(2,7-diaza-spiro[4.4]non-2-yl)-phenyl]-6-hydroxy-2H-isoquinolin-1-one | HCID 68990152 | — |
Reaktionsschritte
According to Method L, (S)-7-[4-(6-methoxy-1-oxo-1H-isoquinolin-2-yl)-phenyl]-2,7-diaza-spiro[4.4]nonane-2-carboxylic acid tert-butyl ester was treated with hydrogen bromide. In this way the product was obtained with molecular weight 361.45 (C22H23N3O2); MS (ESI): 362 (M+H+).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08822495B2 |
| Quelldatensatz | uspto-grants-2014_09 |
| ORD ID | ord-87554a966a0644f581c72498865f0a74 |
| Quellennotiz | uspto-grants-2014_09 |