Propane, 1-bromo-3-fluoro- → 2-{4-[(S)-7-(3-Fluoro-propyl)-2,7-diaza-spiro[4.4]non-2-yl]-phenyl}-6-hydroxy-2H-isoquinolin-1-one

HRID 69443

Reaktionsgleichung

Reaktionsgleichung von HRID 69443
[CH2:1]1[C@@:5]2([CH2:9][CH2:8][NH:7][CH2:6]2)[CH2:4][CH2:3][N:2]1[C:10]1[CH:15]=[CH:14][C:13]([N:16]2[CH:25]=[CH:24][C:23]3[C:18](=[CH:19][CH:20]=[C:21]([OH:26])[CH:22]=3)[C:17]2=[O:27])=[CH:12][CH:11]=1.Br[CH2:29][CH2:30][CH2:31][F:32]>>[F:32][CH2:31][CH2:30][CH2:29][N:7]1[CH2:8][CH2:9][C@@:5]2([CH2:1][N:2]([C:10]3[CH:15]=[CH:14][C:13]([N:16]4[CH:25]=[CH:24][C:23]5[C:18](=[CH:19][CH:20]=[C:21]([OH:26])[CH:22]=5)[C:17]4=[O:27])=[CH:12][CH:11]=3)[CH2:3][CH2:4]2)[CH2:6]1

Komponenten

3

Edukt 2

HCID 67699Propane, 1-bromo-3-fluoro-HCID 689901522-[(S)-4-(2,7-diaza-spiro[4.4]non-2-yl)-phenyl]-6-hydroxy-2H-isoquinolin-1-one

Produkt 1

HCID 689916632-{4-[(S)-7-(3-Fluoro-propyl)-2,7-diaza-spiro[4.4]non-2-yl]-phenyl}-6-hydroxy-2H-isoquinolin-1-one

Versuchsvorschrift

According to Method X, 2-[(S)-4-(2,7-diaza-spiro[4.4]non-2-yl)-phenyl]-6-hydroxy-2H-isoquinolin-1-one was reacted with 1-bromo-3-fluoro-propane. In this way the product was obtained with molecular weight 421.52 (C25H28FN3O2); MS (ESI): 422 (M+H+).

Aufarbeitung

  1. customIn this way the product was obtained with molecular weight 421.52 (C25H28FN3O2)

Quellen und Nachweise

ORD-Eintrag
ord-79f1e2bb22db4ae2a40b86b275ef81e7
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08822495B2

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