HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Isobutylene oxide → 6-Cyclopropylmethoxy-2-{3-fluoro-4-[7-(2-hydroxy-2-methyl-propyl)-2,7-diaza-spiro[4.4]non-2-yl]-phenyl}-2H-isoquinolin-1-one
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Isobutylene oxide | HCID 11208 | — |
| Edukt | 6-cyclopropylmethoxy-2-[4-(2,7-diaza-spiro[4.4]non-2-yl)-3-fluorophenyl]-2H-isoquinolin-1-one | HCID 68991253 | — |
| Produkt | 6-Cyclopropylmethoxy-2-{3-fluoro-4-[7-(2-hydroxy-2-methyl-propyl)-2,7-diaza-spiro[4.4]non-2-yl]-phenyl}-2H-isoquinolin-1-one | HCID 57916632 | — |
Reaktionsschritte
According to Method U, 6-cyclopropylmethoxy-2-[4-(2,7-diaza-spiro[4.4]non-2-yl)-3-fluorophenyl]-2H-isoquinolin-1-one was reacted with 2,2-dimethyl-oxirane. In this way the product was obtained with molecular weight 505.64 (C30H36FN3O3); MS (ESI): 506 (M+H+).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08822495B2 |
| Quelldatensatz | uspto-grants-2014_09 |
| ORD ID | ord-83dd5c9105af4819a1886264c2585574 |
| Quellennotiz | uspto-grants-2014_09 |