1,3-Dioxolane, 2-(bromomethyl)- → 2-((R)-4-[1,3']Bipyrrolidinyl-1'-yl-3-fluoro-phenyl)-6-([1,3]dioxolan-2-ylmethoxy)-2H-isoquinolin-1-one

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	1,3-Dioxolane, 2-(bromomethyl)-	HCID 78068	—
Edukt	2-((R)-4-[1,3']Bipyrrolidinyl-1'-yl-3-fluoro-phenyl)-6-hydroxy-2H-isoquinolin-1-one	HCID 68989350	—
Produkt	2-((R)-4-[1,3']Bipyrrolidinyl-1'-yl-3-fluoro-phenyl)-6-([1,3]dioxolan-2-ylmethoxy)-2H-isoquinolin-1-one	HCID 57916607	—

Reaktionsschritte

2-((R)-4-[1,3′]Bipyrrolidinyl-1′-yl-3-fluoro-phenyl)-6-hydroxy-2H-isoquinolin-1-one was reacted with 2-Bromomethyl-[1,3]dioxolane by method K. The product with the molecular weight of 479.56 (C27H30FN3O4) was obtained in this way; MS (ESI): 480 (M+H+).

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US08822495B2
Quelldatensatz	uspto-grants-2014_09
ORD ID	ord-f085abbd83314c0882a27a64d6d08f74
Quellennotiz	uspto-grants-2014_09