HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Piperidine → 2-Chloro-5-nitro-4-(piperidin-1-yl)pyrimidine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Piperidine | HCID 8082 | — |
| Edukt | 2,4-Dichloro-5-nitropyrimidine | HCID 521266 | — |
| Lösungsmittel | Ethanol | HCID 702 | — |
| Produkt | 2-Chloro-5-nitro-4-(piperidin-1-yl)pyrimidine | HCID 7147257 | — |
Reaktionsschritte
Method 1 was followed using 2,4-dichloro-5-nitropyrimidine (1.0 eq), and piperidine (2.0 eq) in EtOH at 0° C. to rt, yielding after washing with 1M citric acid and 1M HCl (to remove the bis addition product), 2-chloro-5-nitro-4-(piperidin-1-yl)pyrimidine (67%) LCMS (m/z): 242.9 (MH+); LC Rt=4.09 min.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08822497B2 |
| Quelldatensatz | uspto-grants-2014_09 |
| ORD ID | ord-e8307f40214a44f987c44c5c386c7361 |
| Quellennotiz | uspto-grants-2014_09 |