HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Benzonitrile, 4-chloro-3-nitro- → Tert-butyl 1-(4-cyano-2-nitrophenyl)piperidin-3-ylcarbamate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Benzonitrile, 4-chloro-3-nitro- | HCID 13655 | — |
| Edukt | Diisopropylethylamine | HCID 81531 | — |
| Edukt | 3-(Boc-amino)piperidine | HCID 4233041 | — |
| Produkt | Tert-butyl 1-(4-cyano-2-nitrophenyl)piperidin-3-ylcarbamate | HCID 69044928 | 95% |
Reaktionsschritte
Method 1 was followed using 4-chloro-3-nitrobenzonitrile (1.0 eq), 3-(N-Boc-amino) piperidine (1.0 eq), and DIEA (2.4 eq) at 55° C. for 24 hours yielding tert-butyl 1-(4-cyano-2-nitrophenyl)piperidin-3-ylcarbamate (95%). LCMS (m/z): 347.2 (MH+); LC Rt=3.06 min.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08822497B2 |
| Quelldatensatz | uspto-grants-2014_09 |
| ORD ID | ord-860ccf97d2074f9eb5a0742f83cd25f7 |
| Quellennotiz | uspto-grants-2014_09 |