3-Amino-6-bromopyrazine-2-carboxylic acid → HCID 86669180, Verbindung

Beteiligte Stoffe

Reaktionsschritte

Following method 11, tert-butyl 1-(2-amino-4-benzoylphenyl)piperidin-4-ylcarbamate was coupled to 3-amino-6-bromopyrazine-2-carboxylic acid with TEA (1.5 eq) in ACN at 55° C. for 48 hours. Concentrated, triturated in cold ACN, filtered, and dried in vacuo yielding tert-butyl 1-(2-(3-amino-6-bromopyrazine-2-carboxamido)-4-benzoylphenyl)piperidin-4-ylcarbamate (46%). LCMS (m/z): 595.2 (MH+); LC Rt=3.94 min.

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